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Though the concept of animal testing might seem trivial, tests are less simple as smearing cold cream or lip gloss for the face of the rabbit. Animals found in laboratory testing, often proceed through extremely painful experiments and millions die every year. Those that survive the experiments don't get set free, instead they may be euthanized. In cosmetic animal testing; rabbits, guinea pigs, mice and rats can be used. Tests are done on finished products and individual ingredients to look for the products amount of toxicity and power to cause eye or skin irritations, allergies along with other harmful effects. One of the easiest ways that companies can avoid animal testing is to work with products that are actually extensively utilized in human history and still have proven their safety after a while. Companies also can depend on data from natural and synthetic substances that are already previously tested on animals. Computer modeling and databases may be used to determine biological properties of ingredients making risk assessments.