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Though the notion of animal testing might appear trivial, exams are significantly less simple as smearing cold cream or lip gloss on the face of a rabbit. Animals utilized in laboratory testing, often move through extremely painful experiments and millions die each year. Those that survive the experiments avoid getting set free, instead they may be euthanized. In cosmetic animal testing; rabbits, guinea pigs, mice and rats are commonly used. Tests are executed on finished products and individual ingredients to determine the products a higher level toxicity and capability to cause eye or skin irritations, allergies and also other harmful effects. The general way that people persuade each other is dependant on a variety of factors: One of the easiest ways that companies can avoid animal testing is to work with products that are actually extensively utilized in human history and still have proven their safety after a while. Companies also can depend on data from natural and synthetic substances that are already previously tested on animals. Computer modeling and databases may be used to determine biological properties of ingredients making risk assessments.