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Those that support animal testing claim that is a necessary practice. They explain that businesses that rely on animal testing do use humane ways to feed, house and care for the animals. Supporters also claim that alternatives to animal testing aren't as far reaching, lacking the opportunity to figure out how cosmetic products affect living tissue and organs. Jonathan Brandstein, Patrice O'Neal's manager, said your family desired to thank "all with the fans and friends who have expressed an outpouring of love and support for Patrice these past weeks." "Many individuals have lost a close and loved friend; all of us have mislaid a real comic genius' Jonathan Brandstein said in the statement. Charlie Sheen who has been fired through the hit CBS comedy 'Two and a Half Men' in September tweeted: "The entertainment world along with the world at large lost a brilliant man. Patrice O'Neal was a regular guest around the program 'Opie & Anthony Radio Show' and was a familiar face at some New York City TV shows such as "Chappelle Show," "The Office," and "Tough Crowd with Colin Quinn. Patrice O'Neal's death was announced on Twitter by Opie in the Opie & Anthony Radio Show on Sirius/XM satellite radio: 'Yes, it's true that our pal Patrice O'Neal has passed away,' Opie tweeted. 'The funniest and best thinker I've ever known PERIOD. #devastated." The details of his funeral will be updated soon. From the development trend of audio products, the wire is an extremely important aspect sure to enjoy freedom of music. "Get gone the shackles of cable, using wireless method to enjoy music" could be the development direction of public expectations. In the current selection of wireless transmission protocol, 2.4G holdings are still high.