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Though the notion of animal testing might appear trivial, exams are significantly less simple as smearing cold cream or lip gloss on the face of a rabbit. Animals utilized in laboratory testing, often move through extremely painful experiments and millions die each year. Those that survive the experiments avoid getting set free, instead they may be euthanized. In cosmetic animal testing; rabbits, guinea pigs, mice and rats are commonly used. Tests are executed on finished products and individual ingredients to determine the products a higher level toxicity and capability to cause eye or skin irritations, allergies and also other harmful effects. Though the idea of animal testing might appear trivial, testing is not as simple as smearing cold cream or lip gloss about the face of your rabbit. Animals found in laboratory testing, often go through extremely painful experiments and millions die every year. Those that survive the experiments do not get set free, instead they are euthanized. In cosmetic animal testing; rabbits, guinea pigs, mice and rats are commonly used. Tests are performed on finished products and individual ingredients to look for the products degree of toxicity and capacity to cause eye or skin irritations, allergies and other harmful effects. Jonathan Brandstein, Patrice O'Neal's manager, said the family wanted to thank "all with the fans and friends who've expressed an outpouring of love and support for Patrice these past weeks." "Many folks have lost an end and loved friend; all individuals have lost a real comic genius' Jonathan Brandstein said in a very statement. Charlie Sheen who had previously been fired through the hit CBS comedy 'Two and a Half Men' in September tweeted: "The entertainment world as well as the world most importantly lost an excellent man. Patrice O'Neal would have been a regular guest for the program 'Opie & Anthony Radio Show' and would have been a familiar face at some New York City TV shows such as "Chappelle Show," "The Office," and "Tough Crowd with Colin Quinn. Patrice O'Neal's death was announced on Twitter by Opie from the Opie & Anthony Radio Show on Sirius/XM satellite radio: 'Yes, it's true that our pal Patrice O'Neal has gone by away,' Opie tweeted. 'The funniest and greatest thinker I've ever known PERIOD. #devastated." The details of his funeral is going to be updated soon.