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In September 2004 the EU implemented legislation that banned using over 1,000 chemicals of concern in personal care products. The prohibited chemicals were those known or strongly suspected of causing cancer, mutation, or birth defects. The EU ban has served being a wake-up demand many US companies who market a few overseas. In response some companies have replaced toxins in their goods, for example phthalates, parabens, and formaldehyde with non-toxic alternatives. Though the concept of animal testing might seem trivial, tests are less simple as smearing cold cream or lip gloss for the face of the rabbit. Animals found in laboratory testing, often proceed through extremely painful experiments and millions die every year. Those that survive the experiments don't get set free, instead they may be euthanized. In cosmetic animal testing; rabbits, guinea pigs, mice and rats can be used. Tests are done on finished products and individual ingredients to look for the products amount of toxicity and power to cause eye or skin irritations, allergies along with other harmful effects.