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Difficulty concentrating or mind going blank Now, in review, derealization and depersonalization frequently accompany panic attacks and anxiety. In general terms, derealization is a frightening sense of detachment in one?s external environment, and depersonalization can be an quite as frightening a feeling of detachment from self. Both might be absolutely crippling and take you on the turnstiles of your respective perception of insanity. Now, in review, derealization and depersonalization frequently accompany panic attacks and anxiety. In general terms, derealization is a frightening sense of detachment in one?s external environment, and depersonalization can be an quite as frightening a feeling of detachment from self. Both might be absolutely crippling and take you on the turnstiles of your respective perception of insanity.