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Those that support animal testing claim that is a necessary practice. They explain that businesses that rely on animal testing do use humane ways to feed, house and care for the animals. Supporters also claim that alternatives to animal testing aren't as far reaching, lacking the opportunity to figure out how cosmetic products affect living tissue and organs. One of the easiest ways that companies can avoid animal testing is to work with products that are actually extensively utilized in human history and still have proven their safety after a while. Companies also can depend on data from natural and synthetic substances that are already previously tested on animals. Computer modeling and databases may be used to determine biological properties of ingredients making risk assessments.