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Jonathan Brandstein, Patrice O'Neal's manager, said your family desired to thank "all with the fans and friends who have expressed an outpouring of love and support for Patrice these past weeks." "Many individuals have lost a close and loved friend; all of us have mislaid a real comic genius' Jonathan Brandstein said in the statement. Charlie Sheen who has been fired through the hit CBS comedy 'Two and a Half Men' in September tweeted: "The entertainment world along with the world at large lost a brilliant man. Patrice O'Neal was a regular guest around the program 'Opie & Anthony Radio Show' and was a familiar face at some New York City TV shows such as "Chappelle Show," "The Office," and "Tough Crowd with Colin Quinn. Patrice O'Neal's death was announced on Twitter by Opie in the Opie & Anthony Radio Show on Sirius/XM satellite radio: 'Yes, it's true that our pal Patrice O'Neal has passed away,' Opie tweeted. 'The funniest and best thinker I've ever known PERIOD. #devastated." The details of his funeral will be updated soon. One of the easiest ways that companies can avoid animal testing is to work with products that are actually extensively utilized in human history and still have proven their safety after a while. Companies also can depend on data from natural and synthetic substances that are already previously tested on animals. Computer modeling and databases may be used to determine biological properties of ingredients making risk assessments. Mausoleum smells are from the decomposition process, which occurs naturally as the body undergoes the decaying process. Morticians frequently call the offending bodies, "leakers". These mausoleum odors may be terribly overwhelming, and thus of the embalming chemicals as well as the gases coming because of decomposition, they're able to in conjunction with that pose a health hazard to workers and visitors.