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Shampoo, lotion, toner, face cream and fluoride toothpaste - just a few of the many products which we use daily, and which may have been tested on animals. Thousands of services flood the cosmetics aisle every year. For most of these products, animal testing was used at some point in its research and development. Though animal testing in research and drug development still remains common practice, even scientists now agree that alternatives to animal testing can and may help the non-public care and cosmetics industry. Wondering the other ways exist to test products as opposed to animal testing? Alternative methods have been cheaper, safer and supply faster results. Jonathan Brandstein, Patrice O'Neal's manager, said your family desired to thank "all with the fans and friends who have expressed an outpouring of love and support for Patrice these past weeks." "Many individuals have lost a close and loved friend; all of us have mislaid a real comic genius' Jonathan Brandstein said in the statement. Charlie Sheen who has been fired through the hit CBS comedy 'Two and a Half Men' in September tweeted: "The entertainment world along with the world at large lost a brilliant man. Patrice O'Neal was a regular guest around the program 'Opie & Anthony Radio Show' and was a familiar face at some New York City TV shows such as "Chappelle Show," "The Office," and "Tough Crowd with Colin Quinn. Patrice O'Neal's death was announced on Twitter by Opie in the Opie & Anthony Radio Show on Sirius/XM satellite radio: 'Yes, it's true that our pal Patrice O'Neal has passed away,' Opie tweeted. 'The funniest and best thinker I've ever known PERIOD. #devastated." The details of his funeral will be updated soon. Between June 25 and 26, 1876, a combined force of Lakota and Northern Cheyenne led the United States 7th Cavalry in to a battle near the Little Bighorn River in what was then the eastern fringe of the Montana Territory. The engagement is well known by several names: the Battle of Greasy Grass, the Battle of Little Big Horn, and Custer's Last Stand. Perhaps the most well-known action in the Indian Wars, it absolutely was a remarkable victory for Sitting Bull and his awesome forces. They defeated a column of seven hundred men led by George Armstrong Custer; five in the Seventh's companies were annihilated and Custer himself was killed in the engagement together with two of his brothers and a brother-in-law. Known as the battle that left no white survivors, Little Big Horn has inspired more than 1,000 pieces of art, including over 40 films. Here are four of the best... If you think that avoiding drinking during the workweek but spending per night from the party at weekend drinking so much is no matter, your idea isn't true. You can consume over 1,000 calories from drinking (wine, beer, soda, etc) and eating (chicken wings, pizzas, peanuts, etc). It means you may get extra unexpected pounds.