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Jonathan Brandstein, Patrice O'Neal's manager, said your family desired to thank "all with the fans and friends who have expressed an outpouring of love and support for Patrice these past weeks." "Many individuals have lost a close and loved friend; all of us have mislaid a real comic genius' Jonathan Brandstein said in the statement. Charlie Sheen who has been fired through the hit CBS comedy 'Two and a Half Men' in September tweeted: "The entertainment world along with the world at large lost a brilliant man. Patrice O'Neal was a regular guest around the program 'Opie & Anthony Radio Show' and was a familiar face at some New York City TV shows such as "Chappelle Show," "The Office," and "Tough Crowd with Colin Quinn. Patrice O'Neal's death was announced on Twitter by Opie in the Opie & Anthony Radio Show on Sirius/XM satellite radio: 'Yes, it's true that our pal Patrice O'Neal has passed away,' Opie tweeted. 'The funniest and best thinker I've ever known PERIOD. #devastated." The details of his funeral will be updated soon. 5. The concentration of their language The general way that people persuade each other is dependant on a variety of factors: Now, in review, derealization and depersonalization frequently accompany panic attacks and anxiety. In general terms, derealization is a frightening sense of detachment in one?s external environment, and depersonalization can be an quite as frightening a feeling of detachment from self. Both might be absolutely crippling and take you on the turnstiles of your respective perception of insanity.