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5. The concentration of their language Metoprolol can be an anti-hypertensive (blood pressure) drug classified like a selective beta-1 receptor blocker, also called a beta adrenergic blocker. Metoprolol is sold within the brands Lopressor and Toprol-XL and is also accessible in immediate-release and prolonged-release formulations. In addition to high blood pressure, metoprolol is prescribed to treat conditions including angina pectoris (chest pain) abnormal heart rhythms, migraine, tremors, congestive heart failure, bleeding through the esophagus, negative effects of antipsychotics, and to prevent second strokes. Kankles (or cankles which is the proper spelling) is really a term that occurred inside a movie 'Shallow Hal' in the early 90's. I am sure it was probably around before then, getting used to create fun of others in high school graduation, or to have a laugh at someone's expense. However, many don't find any humor within it in any respect, and is arguably panic or anxiety attack on someone's self esteem. Cankles is when your ankle and calf don't have any curvature hence the merging with the words in order to create Cankles.