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Jonathan Brandstein, Patrice O'Neal's manager, said the family wanted to thank "all in the fans and friends who've expressed an outpouring of love and support for Patrice these past weeks." "Many of us have mislaid an in depth and loved friend; all of us have lost a genuine comic genius' Jonathan Brandstein said in a very statement. Charlie Sheen who had been fired through the hit CBS comedy 'Two and a Half Men' in September tweeted: "The entertainment world and also the world most importantly lost a brilliant man. Patrice O'Neal would have been a regular guest around the program 'Opie & Anthony Radio Show' and was a familiar face at some New York City TV shows including "Chappelle Show," "The Office," and "Tough Crowd with Colin Quinn. Patrice O'Neal's death was announced on Twitter by Opie in the Opie & Anthony Radio Show on Sirius/XM satellite radio: 'Yes, it's true that our pal Patrice O'Neal has passed away,' Opie tweeted. 'The funniest as well as thinker I've ever known PERIOD. #devastated." The details of his funeral is going to be updated soon. 1. The attractiveness of the person Famous battle sites, man-made wonders, Mother Nature in all her splendor and World Heritage Sites are all listed in their itineraries. World renowned game parks where people can view Africa's Big 5 in their natural surroundings and natural splendors such as Vic Falls give tourists an all encompassing appreciation for this continent and its wonders. Those that support animal testing point out that is often a necessary practice. They mention that firms that depend upon animal testing do use humane ways to feed, house and care for the animals. Supporters also are convinced that choices to animal testing aren't as far reaching, lacking a chance to figure out how cosmetic products affect living tissue and organs.